Optimal Radiation Dose For Stage III Lung Cancer – Should “Definitive” Radiation Doses Be Used in the Pre-Operative Setting?
نویسندگان
چکیده
منابع مشابه
Locoregional tumor failure after definitive radiation for patients with stage III non-small cell lung cancer
BACKGROUND Locoregional tumor failure (LRF) after definitive chemoradiation for patients with stage III NSCLC remains unacceptably high. This analysis sought to further define where LRF occurs relative to radiation dose received and pre-treatment PET scan-defined maximum standard uptake value (SUVmax). METHODS This was a retrospective study analyzing patients with stage III NSCLC treated with...
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For patients with stage III non-small-cell lung cancer with unresectable or inoperable tumors, definitive chemoradiotherapy is often utilized. Historically, local control and overall survival rates have been poor. In an effort to improve local control, new chemotherapeutic agents in combination with higher doses of radiotherapy have been investigated. Early dose escalation trials date back to t...
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PURPOSE The results from Radiation Therapy Oncology Group (RTOG) 0617, a dose escalation trial that compared treatment with 60 Gy versus 74 Gy for patients with stage III non-small cell lung cancer (NSCLC), suggested that in these patients, the heart dose from radiation therapy correlates with survival. In particular, the study noted that patients with a high heart V5 and V30 had a poorer overa...
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Background Lung cancer remains one of the deadliest cancers with late detection and high mortality rates. Results of the NLST trial published in 2011 demonstrated a 20% decrease in lung cancer mortality in the CT arm compared to the radiography arm. One of the biggest concerns of wide implementation of lung cancer screening by CT, is radiation risk and radiation-induced cancer. We present vario...
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Historical Background ABSTRACT Strong sources of radiation became available in the 1950s. Since then, intense ionizing beams have been employed against cancer to destroy or shrink tumors. Today, nearly all radiation treatments for cancer apply high doses to local regions of the body. It is generally believed that radiation in any amount will only damage cells and that the mutated cells could be...
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ژورنال
عنوان ژورنال: JTO Clinical and Research Reports
سال: 2021
ISSN: 2666-3643
DOI: 10.1016/j.jtocrr.2021.100201